Fig. 2. Effect of nobiletin on plasma levels of TC (A), ratios of LDL/VLDL- and HDL-cholesterol to TC (B), and plasma levels of triglyceride (C), CRP (D), oxLDL (E), paraoxonase (F), and adipocytokines (G, H) in HCD-fed mice. Values are presented as mean ± SE (n = 12). Values are significantly different between the groups, according to Student's t-test.

TC, total cholesterol; ND, normal diet; HCD, high-cholesterol diet (35 kcal% fat, 1.25% cholesterol, 0.5% cholic acid); HCD + NOB, high-cholesterol diet plus nobiletin (0.02%); LDL/VLDL-C, low-density lipoprotein/very low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol; CRP, C-reactive protein; oxLDL, oxidized low-density lipoprotein; IL, interleukin; PAI-1, plasminogen activator inhibitor-1.

^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ND vs. HCD; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, HCD vs. HCD + NOB.