Table 1.

Experimental Design

Exp. Groups	Day 1-Day 2	Day 3-Day 9	Day 10-Day 16
N (n = 6)	–	–	–
NSC (n = 6)	NSC (50 mg/kg/day, P.O.)	NSC (50 mg/kg/day, P.O.)	NSC (50 mg/kg/day, P.O.)
CRID3 (n = 6)	CRID3 (20 mg/kg/day, P.O.)	CRID3 (20 mg/kg/day, P.O.)	CRID3 (20 mg/kg/day, P.O.)
DSS (n = 10)	–	4% DSS in drinking water	–
DSS/NSC (n = 8)	NSC (50 mg/kg/day, P.O.)	NSC (50 mg/kg/day, P.O.) + 4% DSS in drinking water	NSC (50 mg/kg/day, P.O.)
DSS/CRID3 (n = 8)	CRID3 (20 mg/kg/day, P.O.)	CRID3 (20 mg/kg/day, P.O.) + 4% DSS in drinking water	CRID3 (20 mg/kg/day, P.O.)
DSS/NSC/CRID3 (n = 8)	NSC (50 mg/kg/day, P.O.) + CRID3 (20 mg/kg/day, P.O.)	NSC (50 mg/kg/day, P.O.) + CRID3 (20 mg/kg/day, P.O.) + 4% DSS in drinking water	NSC (50 mg/kg/day, P.O.) + CRID3 (20 mg/kg/day, P.O.)

Abbreviations: CRID3, cytokine release inhibitory drug 3; DSS, dextran sodium sulphate; NSC, NSC328382; P.O., by oral route.