Figure 10.

Editing reduction at individual sites in cytosolic-enriched RNA in ADAR deficiency.(A–C) Average high-confidence raw counts (n = 2) of adenosines (green) and guanosines (= A-to-I edits, orange) at all high-confidence editing sites in exemplary ECRs located to introns in BRD8 (A), MIGA1 (B), or PSPH (C). Shown are data from cytosolic RNA extracts of cas9-transgenic WT THP-1. Deficiencies are indicated. Data are from two independent experiments. A, adenosine; CTRL, nontarget control; G, guanosine.