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. 2021 May 20;99(8):1151–1171. doi: 10.1007/s00109-021-02089-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — LMO3 promotes mitochondrial oxidative capacity in human mature adipocytes. A Experimental scheme for silencing LMO3 in human mature adipocytes. Photomicrographs show mature adipocytes 4 days after siRNA transfection. B Q-PCR analysis of selected genes from siCtrl or siLMO3-transfected human mature adipocytes (n = 5–7). C OCR of siCtrl- or siLMO3-transfected human mature adipocytes (n = 8–11). D OCR and mitochondrial function parameters of siCtrl- or siLMO3-transfected human mature adipocytes (n = 8–11). E OCR of AdLacZ- or AdLmo3-transduced human mature adipocytes (n = 11). F OCR and mitochondrial function of AdLacZ- or AdLmo3-transduced human mature adipocytes (n = 11). G Rank order of 281 human white adipocyte genes correlating with forskolin treatment (forskolin vs. vehicle, P-value < 0.005) obtained from public data [41]. H GSEA of genes induced in “brite” adipocytes [41] in siCtrl- versus siLMO3-transfected mature human adipocytes. P-value of the Nominal Enrichment Score for the indicated gene set is indicated. I GSEA of adipocyte LMO3 target genes in WAT derived from metabolically “healthy” (MHO) or “unhealthy” (MUO) morbidly obese patients based on HOMA-IR [42] using a custom gene set composed of LMO3-regulated genes in human mature adipocytes. Note that LMO3-induced genes are enriched in MHO patients. NES P-value < 0.0001 for both, omental and subcutaneous WAT. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant