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. Author manuscript; available in PMC: 2022 Jan 27.
Published in final edited form as: J Am Chem Soc. 2021 Jan 12;143(3):1296–1300. doi: 10.1021/jacs.0c12044

Figure 2.

Figure 2.

Tyrosinase activity A) and melanin content B) upon treatment with ASO-PR10, DNA-PR10 with a scrambled sequence (Scr-PR10), PR-devoid micelles (in PBS), or free PR (in DMSO). α-MSH is used stimulate melanogenesis. Tyrosinase activity and melanin content are recorded as percent changes compared with α-MSH-treated cells (2 to 20 μM PR, 48 h treatment). PR-devoid micelles: 1 μM ASO. C,D) MCIR levels in B16F10 cells after treatment with PR, ASO-PR10, and controls (2 to 20 μM PR, 72 h treatment) as determined by western blot analysis. DNA-lipofectamine2k complexes: 10 μM ASO. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 (two-tailed test).