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A, The inside of MK-8666 binding pocket of representative structures extracted from clustering analysis. B, The angle β evolves with time. C, The side chain dihedral of Tyr240 evolves with time (GPR40-MK6: pink; GPR40-apo: green; GPR40-MK6-AP8: blue; GPR40-AP8: orange). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
