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. 2021 Jul 26;4:914. doi: 10.1038/s42003-021-02430-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Kaplan–Meier survival analysis of all MPM patients demonstrates that patients with epithelioid subtype (Epi.) had better survival than those with nonepithelioid subtype (non-Epi.) with a median survival of 28.6 (Epi.) versus 15.9 months (non-Epi.) (P < 0.0001). b GITR and GITRL levels by immunohistochemistry in epithelioid and nonepithelioid MPM; immunohistochemistry results were quantified by Definiens Tissuestudio 4.0 software. *P < 0.05, determined by Mann–Whitney U test. c Correlation between expression of GITR and GITRL (p = 0.0018, r = 0.3115). d Risk analysis of patients with epithelioid and nonepithelioid subtype who died from mesothelioma after the SMART approach to determine the correlation between GITRL and GITR and length of survival. e Kaplan–Meier survival analysis in nonepithelioid MPM showed that high expression of GITRL and GITR was associated with worse survival after SMART. In epithelioid MPM, high expression of GITRL was associated with better survival after SMART.