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. 2021 Jan 27;26(9):4853–4863. doi: 10.1038/s41380-021-01030-3

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

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Fig. 5 — Overall, the present analyses suggest that psychiatric disorders are impacted at physiologic levels of biological complexities, with changes at the chromosome level emanating up to cell-type, drug-target, and pathway levels. Collectively these alterations generate various phenotypes, largely related to cognition, which contribute to disease. The present subgroups show similarities and differences across all of these levels, with Subgroup 1 and Subgroup 3 showing the most similarities, and Subgroup 2 showing the most differences.