Table 2.
The associations between VO2peak normalized for lean mass, and the circulating proteins: sex- and multivariable adjusted linear regression. Only proteins that met the Bonferroni adjusted threshold (p<0.0006) in the primary sex adjusted analyses are presented. Proteins that met p<0.05 threshold in the multivariable-adjusted analyses are highlighted in bold
| Protein | Sex-adjusted | Multivariable-adjusted† | ||||||
|---|---|---|---|---|---|---|---|---|
| beta | 95% CI | 95% CI | p-value | beta | 95% CI | 95% CI | p-value | |
| low | high | low | high | |||||
| Fatty acid-binding protein 4 (FABP4) | −.41 | −.49 | −.32 | <0.0001 | −.17 | −.25 | −.09 | <0.0001 |
| Interleukin-6 (IL-6) | −.34 | −.43 | −.25 | <0.0001 | −.21 | −.31 | −.10 | 0.00015 |
| Leptin | −.36 | −.43 | −.29 | <0.0001 | −.09 | −.15 | −.04 | 0.001 |
| Galanin | .25 | .16 | .35 | <0.0001 | .18 | .07 | .29 | 0.002 |
| Cystatin-B (CSTB) | −.31 | −.40 | −.21 | <0.0001 | −.16 | −.27 | −.05 | 0.0046 |
| Interleukin-1 receptor antagonist protein (IL-1RA) | −.39 | −.48 | −.30 | <0.0001 | −.13 | −.23 | −.03 | 0.0085 |
| Kallikrein-6 (KLK6) | .18 | .08 | .27 | 0.0003 | .15 | .03 | .26 | 0.012 |
| Heparin-binding EGF-like growth factor (HB-EGF) | .18 | .08 | .28 | 0.00029 | .12 | .01 | .24 | 0.037 |
| Growth/differentiation factor 15 (GDF-15) | −.19 | −.29 | −.09 | 0.00013 | −.11 | −.23 | .00 | 0.049 |
| Tissue-type plasminogen activator (t-PA) | −.33 | −.42 | −.24 | <0.0001 | −.10 | −.19 | .00 | 0.054 |
| Cathepsin D (CTSD) | −.26 | −.35 | −.17 | <0.0001 | −.04 | −.14 | .06 | 0.46 |
| Hepatocyte growth factor (HGF) | −.25 | −.35 | −.16 | <0.0001 | −.02 | −.13 | .08 | 0.67 |
| E-selectin (SELE) | −.23 | −.33 | −.14 | <0.0001 | −.07 | −.18 | .04 | 0.20 |
| Stem cell factor (SCF) | .23 | .13 | .32 | <0.0001 | .10 | −.01 | .22 | 0.073 |
| Vascular endothelial growth factor D (VEGF-D) | .18 | .09 | .27 | <0.0001 | .06 | −.04 | .16 | 0.26 |
| Follistatin (FS) | −.19 | −.29 | −.09 | 0.00012 | −.07 | −.18 | .05 | 0.25 |
| Fibroblast growth factor 23 (FGF-23) | −.17 | −.27 | −.08 | 0.0004 | −.10 | −.21 | .01 | 0.084 |
| Tumor necrosis factor ligand superfamily member 14 (TNFSF14) | −.17 | −.27 | −.07 | 0.00057 | .04 | −.07 | .15 | 0.47 |
†Multivariable linear regression further adjusted for fat mass (DXA), fasting glucose (mmol/L), LDL (mmol/L), WHR, smoking status, blood pressure (mmHg), educational level, and lpnr (lab test sequence number)