Table 3.
Association Between Secondary Hyperparathyroidism Treatment (Parathyroidectomy vs Cinacalcet) and Post–Kidney Transplant (KT) Adverse Outcomes. Odds Ratio of Acute Rejection and Delayed Graft Function, Hazard Ratio of Death-Censored Graft Failure, All-Cause Graft Failure and Death.
| Unadjusted HR (95% CI) |
Adjusted for pre-KT factorsa HR (95% CI) |
Adjusted for additional peri-operative KT factorsb HR (95% CI) |
|
|---|---|---|---|
| Discharge | 1.21 (1.06–1.39)* | 1.13 (0.91–1.41) | 1.13 (0.91–1.41) |
| Delayed graft function | 1.00 (0.74–1.35) | 1.13 (0.83–1.53) | 1.04 (0.76–1.41) |
| Acute rejection | 0.93 (0.58–1.48) | 0.78 (0.49–1.26) | 0.82 (0.51–1.31) |
| Death-censored graft failure | 1.51 (1.01–2.27)* | 1.40 (0.93–2.11) | 1.50 (1.00–2.27) |
| All-cause graft failure | 1.25 (0.89–1.77) | 1.31 (0.92–1.86) | 1.37 (0.96–1.95) |
| Death | 0.87 (0.49–1.54) | 1.16 (0.65–2.08) | 1.15 (0.64–2.07) |
*
p < 0.05
a
Adjusted for age, sex, race, education, body mass index, cause of kidney failure, peak panel reactive antigen, history of malignancy, diabetes, hypertension, calendar year of dialysis initiation
b
Adjusted for (1) + years on dialysis, human leukocyte antigen mismatch, cold ischemic time, ABO incompatibility, calendar year of transplant, type of induction, and donor factors (age, sex, race, deceased donor, expanded criteria donor