Table 2.

Prognostic performance of the predictive and actual molecular groups for predicting PFS and OS.

WHO grade	Dataset	Predictive molecular groups PFS C-index (95% CI)	Actual molecular groups PFS C-index (95% CI)	P value	Predictive molecular groups OS C-index (95% CI)	Actual molecular groups OS C-index (95% CI)	P value
II–IV	Training	0.757 (0.724–0.791)	0.745 (0.709–0.781)	0.946	0.759 (0.720–0.798)	0.764 (0.730–0.800)	0.911
	Validation	0.709 (0.656–0.763)	0.722 (0.666–0.778)	0.241	0.703 (0.644–0.762)	0.751 (0.696–0.806)	0.359
II/III	Training	0.743 (0.676–0.810)	0.739 (0.678–0.799)	0.918	0.752 (0.681–0.823)	0.778 (0.722–0.835)	0.540
	Validation	0.707 (0.624–0.790)	0.638 (0.538–0.737)	0.254	0.703 (0.611–0.796)	0.715 (0.622–0.810)	0.819
IV	Training	0.530 (0.476–0.585)	0.538 (0.468–0.608)	0.879	0.534 (0.481–0.588)	0.500 (0.431–0.568)	0.296
	Validation	0.542 (0.456–0.628)	0.528 (0.430–0.626)	0.824	0.542 (0.459–0.626)	0.522 (0.422–0.621)	0.742

WHO World Health Organization, PFS progression-free survival, OS overall survival, CI confidence interval.