TABLE 1.
Different animal models have been used to prove that catalpol improves AS.
| As in vivo model | Drug administration route | Catalpol dose | Processing time | Reference |
|---|---|---|---|---|
| High cholesterol rabbit | Oral administration | 5 mg/kg/d | 12 w | Liu and Zhang. (2015) |
| Diabetic rabbit | Oral administration | 5 mg/kg/d | 12 w | Liu et al. (2016) |
| LDLr−/− mice + HFD1 | Oral administration | 100 mg/kg/d | 16 w | Zhang et al. (2018) |
| 200 mg/kg/d | ||||
| ApoE−/−mice + HFD2+ Ovx | Oral administration | 20 mg/kg/d | 90 d | Chen et al. (2021) |
Note: High cholesterol rabbit (induced by feeding rabbit feed containing 1% cholesterol); Diabetic rabbit (induced by intravenous injection of alloxan 100 mg/kg after 4 weeks of high-fat diet containing 1% cholesterol and 10% lard); LDLr−/− mice:low density lipoprotein receptor knockout mice; HFD1 (high-fat diet: contains 20.0% cocoa fat, 1.25% cholesterol, 22.5% protein and 45.0% carbohydrates); ApoE−/− mice: apolipoprotein E-knockout mice; HFD2 (high-fat diet: containing 0.3% cholesterol and 20% pork fat); Ovx: ovariectomy.