TABLE 1.
| Demographic characteristics of 311 pediatric patients with ALL.
| Characteristics | Median (range) |
|---|---|
| Demographics | |
| Male (n, %) | 197 (63.3) |
| Age, years | 5.0 (0.75–15.2) |
| Height, cm | 112 (67–175) |
| Body weight, kg | 19.0 (4.5–113.0) |
| Biochemical test | |
| Albumin, g/L | 43.4 (23.8–56.5) |
| Total protein, g/L | 63.4 (17.4–78.6) |
| Total bilirubin, µmol/L | 5.9 (1.5–114.0) |
| Direct bilirubin, µmol/L | 1.9 (0.1–45.0) |
| AST, U/L | 22.6 (7.0–319.0) |
| ALT, U/L | 16.0 (2.0–390) |
| Serum creatinine, µmol/L | 26.0 (8.0–135.0) |
| MTX dosage regimen [n (course)] | |
| 5 g/m2 | 142 (464) |
| 4 g/m2 | 47 (84) |
| 3 g/m2 | 154 (524) |
| 2 g/m2 | 42 (107) |
| 1 g/m2 | 28 (71) |
| Concomitant medication [n (course)] | |
| Dasatinib | 13 (48) |
| Imatinib | 4 (14) |
| Omeprazole | 59 (142) |
| Sulphonamides | 14 (15) |
| NSAIDs | 24 (25) |
| Penicillin | 6 (6) |
Notes: The demographic data were summarized from 1,250 cycles of MTX chemotherapy. ALT: alanine transaminase, AST: aspartate transaminase.