Figure 1.

(a−c) Microscopic examination by light microscopy of kidney biopsy specimens from patients 1, 2, and 3, respectively, reveals relatively normal glomeruli. Periodic acid−Schiff, original magnification ×40. Bar = 50 μm (for each figure part). Immunofluorescent studies from all biopsy specimens show no evidence of immune complex deposits (not shown). (d−f) Electron microscopy examination of kidney biopsy specimens from patients 1, 2, and 3, respectively, shows diffuse effacement of foot processes of podocytes (arrows) without evidence of immune-type dense deposits. Transmission electron microscopy, original magnification ×3000. Large bar, 5 × 2 μm =10 μm (for each figure part).