Table 2.
Participant quality of life, disability scores and serology.
| HC | ME/CFS | P-value | |
|---|---|---|---|
| SF-36 (%) | |||
| Physical Functioning | 93.33 ± 5.528 | 30.78 ± 7.297 | 0.0002 |
| Physical Role | 99.31 ± 0.6944 | 15.97 ± 8.597 | <0.0001 |
| Pain | 91.94 ± 3.859 | 41.94 ± 7.117 | <0.0001 |
| General Health | 83.33 ± 4.39 | 34.25 ± 6.544 | <0.0001 |
| Social Functioning | 100 ± 0 | 19.44 ± 8.866 | <0.0001 |
| Emotional Role | 100 ± 0 | 71.3 ± 12.51 | 0.0090 |
| Emotional Wellbeing | 79.94 ± 2.922 | 42.28 ± 3.577 | <0.0001 |
| WHO DAS (%) | |||
| Communication & Understanding | 2.78 ± 1.840 | 40.74 ± 4.436 | <0.0001 |
| Mobility | 1.67 ± 1.66 | 51.11 ± 8.571 | <0.0001 |
| Self-Care | 0 ± 0 | 25.0 ± 8.398 | 0.0090 |
| Interpersonal Relationships | 0 ± 0 | 34.72 ± 7.591 | 0.0004 |
| Life Activities | 0 ± 0 | 63.89 ± 10.77 | <0.0001 |
| Participation in Society | 0.69 ± 0.69 | 55.17 ± 9.372 | <0.0001 |
| Full Blood Count | |||
| White Cell Count (x109/L) | 5.79 ± 0.42 | 5.711 ± 0.6647 | 0.9223 |
| Lymphocytes (x109/L) | 1.95 ± 0.23 | 2.039 ± 0.2975 | 0.8085 |
| Neutrophils (x109/L) | 3.14 ± 0.23 | 3.05 ± 0.346 | 0.5457 |
| Monocytes (x109/L) | 3.14 ± 0.25 | 0.453 ± 0.06 | 0.7819 |
| Eosinophils (x109/L) | 0.19 ± 0.02 | 0.134 ± 0.03 | 0.0333 |
| Basophils (x109/L) | 0.05 ± 0.004 | 0.04 ± 0.01 | 0.3532 |
| Platelets (x109/L) | 304.1 ± 19.64 | 275.3 ± 15.47 | 0.2667 |
| Red Cell Count (x1012/L) | 4.38 ± 0.15 | 4.52 ± 0.177 | 0.5606 |
| Haematocrit | 0.41 ± 0.01 | 0.412 ± 0.01 | 0.7391 |
| Haemoglobin (g/L) | 132.6 ± 3.81 | 136.8 ± 4.71 | 0.4958 |
SF-36 and WHODAS scores were analysed using participant questionnaire responses. Results from routine full blood were analysed in ME/CFS patients taking LDN and HC. Data are presented as mean ± SEM. Abbreviations: HC, healthy controls; ME/CFS, myalgic encephalomyelitis/chronic fatigue syndrome; SF-36, 36-item short form survey; WHO, world health organization; DAS, disability assessment schedule.