Table 2.
Univariate and multivariate logistic regression analysis for the risk factors of CIP.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age (≥65 vs. <65) | 1.59 (0.87–2.9) | 0.13 | – | – |
| Gender (female vs. male) | 1.67 (0.78–3.5) | 0.19 | – | – |
| Smoking (current or former vs. never) | 1.15 (0.63–2.1) | 0.65 | – | – |
| ECOG PS (≥2 vs. <2) | 0.35 (0.12–1.02) | 0.054 | 0.38 (0.12–1.17) | 0.09 |
| Prior radiation | 2.26 (0.95–5.36) | 0.06 | 1.95 (0.75–5.02) | 0.19 |
| Histology (squamous vs. non-squamous) | 3.86 (1.89–7.87) | <0.001 | 3.02 (1.41–6.43) | 0.004 |
| Treatment line (≥2nd vs. 1st) | 1.66 (0.82–3.36) | 0.16 | – | – |
| Treatment (monotherapy vs. combination) | 9.48 (2.72–33.04) | <0.001 | 6.56 (1.79–23.98) | 0.004 |
Bold values indicate p < 0.05; CIP, checkpoint inhibitor-related pneumonitis; ECOG PS, Eastern Cooperative Oncology Group performance status; OR, odds ratio; CI, confidence interval.