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. 2021 Jul 9;134(13):jcs253484. doi: 10.1242/jcs.253484

Fig. 4.

Fig. 4.

Mutation of LATS phosphorylation sites reduces the rate of YAP1 nuclear export. (A) Boxplot of the nuclear import and export rate constants for Zdk–Flag–mCherry–YAP1-WT, Zdk–Flag–mCherry–YAP1-5SA and Zdk–Flag–mCherry–YAP1-S94A, derived using the opto-release methodology. n≥15 cells per condition from three experiments. Boxes show the interquartile range, lines indicate the median and whiskers show the 10–90th percentiles. **P<0.01 (Mann–Whitney test). (B) Scatterplot of import versus export rate constants for Zdk–Flag–mCherry–YAP1-WT, Zdk–Flag–mCherry–YAP1-5SA, Zdk–Flag–mCherry–YAP1-S94A. n=49 from >3 experiments. Spearman's correlation coefficient (r) and significance are shown.