Table 3.
Composition of liposomes-based vaccines for malaria prophylaxis
| Antigens | Lipid composition | Ratioa | References |
|---|---|---|---|
| R32tet32 |
DMPC: cholesterol: dicetylphosphate: lipid A DMPC: cholesterol: DMPG: lipid A DMPC: cholesterol: dicetylphosphate: lipid A (± alum) DMPC: cholesterol: DMPG: lipid A (± alum) |
1:0.75:0.1:0.02 0.9:0.75:0.1:0.02 1:0.75:0.1:0.02 (± 20 nmol/µmol of phospholipid) 0.9:0.75:0.1:0.02 (± 20 nmol/µmol of phospholipid) |
[226, 227] |
| R32NS181 | Cholesterol: DMPC: DMPG (± MPLA) | 0.75:0.9:0.1 (± 52.6 µg/µmol lipid) | [228] |
| R32NS1 | DMPC: DMPG: cholesterol: lipid A |
1.8:0.2:1.5:0.04 1.8:0.2:1.5:0.005 |
[229] |
| RTS,S | DMPC: cholesterol: DMPG (± MPLA) | 0.9:0.75:0.1 (± 0.2 µg/dose) | [230] |
| 66PyIMP | EPC: cholesterol | 2:1 | [231] |
| RTS,S | DOPC: cholesterol: MPLA: QS21b | 1:250:50:50 (w/w) | [204, 223] |
| PfMSP-119 | SPC: Span 80 | 86:14 (w/w) | [232] |
|
FMP013 FMP014 |
DMPC: DMPG: cholesterol: MPLA: QS21c | 6986.27:788.73:5.413:200:100 (w/w) | [233, 234] |
| Pf25 | DPPC: cholesterol: CoPoP: PHAD | 4:2:1:1 (w/w) | [235] |
aUnless otherwise indicated, the ratio is expressed in molar
bThis mixture represent the composition of AS01-type liposome
cThis mixture represent the composition of ALFQ-type liposome