Table 5.
The most significant enriched terms (potential function and pathway of target genes) based on biological process GO† enrichment of the novel candidate miRNAs in the esophageal tissues.
| miRNA | Enriched Term | Target genes | A p-value* |
|---|---|---|---|
| 2:46348793..46348872 | Positive_regulation_of_neurotransmitter_transport_(GO:0051590) | DTNBP1 | 0.024 |
| Positive_regulation_of_neurotransmitter_secretion_(GO:0001956) | 0.024 | ||
| Anterograde_axon_cargo_transport_(GO:0008089) | 0.024 | ||
| Axon_cargo_transport_(GO:0008088) | 0.03 | ||
| Regulation_of_neurotransmitter_secretion_(GO:0046928) | 0.03 | ||
| Regulation_of_neurotransmitter_transport_(GO:0051588) | 0.03 | ||
| 3:186787298..186787358 | Neuroepithelial_cell_differentiation_(GO:0060563) | MITF | 0.046 |
| 6:104646203...104646269 | Cellular_response_to_interleukin-6_(GO:0071354) | GALT | 0.039 |
| Interleukin-6-mediated_signaling_pathway_(GO:0070102) | 0.027 | ||
| Response_to_interleukin-6_(GO:0070741) | 0.04 | ||
| 7:53776229...53776317 | Positive_regulation_of_interleukin8_biosynthetic_process_(GO:0045416) | PRG3 | 0.031 |
| Regulation_of_interleukin-8_production_(GO:0032677) | 0.031 | ||
| 15:60128283...60128360 | Neuron_projection_regeneration_(GO:0031102) | NEFL | 0.02 |
| Axon_development_(GO:0061564) | 0.02 | ||
| Axon_regeneration_(GO:0031103) | 0.02 | ||
| Anterograde_axon_cargo_transport_(GO:0008089) | 0.02 | ||
| Neurofilament_cytoskeleton_organization_(GO:0060052) | 0.02 | ||
| Axon_cargo_transport_(GO:0008088) | 0.02 | ||
| Response_to_axon_injury_(GO:0048678) | 0.02 | ||
| Positive_regulation_of_axonogenesis_(GO:0050772) | 0.024 | ||
| Negative_regulation_of_neuron_apoptotic_process_(GO:0043524) | 0.036 | ||
| Regulation_of_axonogenesis_(GO:0050770) | 0.036 | ||
| Negative_regulation_of_neuron_death_(GO:1901215) | 0.037 | ||
| Regulation_of_neuron_apoptotic_process_(GO:0043523) | 0.04 | ||
| Positive_regulation_of_neuron_differentiation_(GO:0045666) | 0.044 | ||
| Regulation_of_neuron_death_(GO:1901214) | 0.044 | ||
| Regulation_of_neuron_projection_development_(GO:0010975) | 0.046 | ||
| Positive_regulation_of_neurogenesis_(GO:0050769) | 0.047 | ||
| 20:38425194..38425268 | Cellular_response_to_nerve_growth_factor_stimulus_(GO:1990090) | RAP1A | 0.032 |
| Response_to_nerve_growth_factor_(GO:1990089) | RAP1A | 0.032 | |
| Positive_regulation_of_calcium_ion_transmembrane_transporter_activity_(GO:1901021) | ANK2 | 0.032 | |
| Negative_regulation_of_neurotransmitter_transport_(GO:0051589) | RAP1A | 0.032 | |
| Nerve_growth_factor_signaling_pathway_(GO:0038180) | RAP1A | 0.032 | |
| Negative_regulation_of_neurotransmitter_secretion_(GO:0046929) | RAP1A | 0.032 | |
| Regulation_of_neurotransmitter_secretion_(GO:0046928) | RAP1A | 0.047 | |
| 6:77781479...77781527 | Regulation_of_intrinsic_apoptotic_signaling_pathway_by_p53_class_mediator_(GO:1902253) | RRM2B | 0.004 |
| Negative_regulation_of_signal_transduction_by_p53_class_mediator_(GO:1901797) | 0.005 | ||
| Regulation_of_signal_transduction_by_p53_class_mediator_(GO:1901796) | 0.006 | ||
| Regulation_of_intrinsic_apoptotic_signaling_pathway_(GO:2001242) | 0.014 | ||
| Negative_regulation_of_apoptotic_signaling_pathway_(GO:2001234) | 0.018 | ||
| Regulation_of_apoptotic_signaling_pathway_(GO:2001233) | 0.028 | ||
| 12:29562570..29562639 | Calcium-mediated_signaling_using_intracellular_calcium_source_(GO:0035584) | HOMER2 | 0.039 |
| Regulation_of_interleukin-8_biosynthetic_process_(GO:0045414) | PRG3 | 0.039 | |
| Mast_cell_activation_involved_in_immune_response_(GO:0002279) | PLA2G3 | 0.039 | |
| Positive_regulation_of_interleukin-8_biosynthetic_process_(GO:0045416) | PRG3 | 0.039 | |
| Axoneme_assembly_(GO:0035082) | PLA2G3 | 0.042 |