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Lateral flow devices use a streptavidin labeled strip on nitrocellulose paper to anchor a capture PNA (red). The target oligonucleotide (blue) and the detection PNA probe (red) are then allowed to run the length of the strip. If the target is present, it will act as a hybridization scaffold bringing the two PNAs in proximity. This allows for either simple ligation (A) or fluorogenic ligation (B) which generates an optical signal allowing for detection of the target.
