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. 2021 Jul 13;13:684171. doi: 10.3389/fnagi.2021.684171

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Copyright © 2021 Rehman, Tar, Olamide, Li, Kassubek, Böckers, Weishaupt, Ludolph, Wiesner and Roselli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tbk1 blockade modifies the chemokine profile after Stab Wound Injury (SWI) injury. qPCR from whole-biopsy homogenates were obtained from the injury site (or the corresponding anatomical location in sham mice) from animals treated with either vehicle or AMX at 7 dpi. AMX strongly downregulated the expression of CCL-5 (B), CCL-7 (C), CCL-3 (D), CCL-3 (E), CCL-12 (F) but not of CCL-2 (A), and strongly upregulated the expression of CXCL1 (G). Expression of the complement factor C3 was unchanged (H). (n = 3 animals/group with 4 sections/animal. Average ± SD, plus individual data points indicated; two-way ANOVA with Tukey post hoc; ns: not significant, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^****p < 0.0001; full statistical report in Supplementary Table 9).