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. Author manuscript; available in PMC: 2022 May 6.
Published in final edited form as: Mol Cell. 2021 Apr 13;81(9):1905–1919.e12. doi: 10.1016/j.molcel.2021.02.033

Figure 3: Metabolite Analysis in LUC7L2-Depleted Cells Reveals Crossovers at Phosphofructokinase and System Xc−. See also Figure S3 and Table S2–3.

Figure 3:

(A) Intracellular levels of metabolites in LUC7L2KO K562 cells as determined by LC-MS. (B) Extracellular levels of metabolites as determined by LC-MS analysis of the spent media from (A). Positive and negative values illustrate metabolite secretion and consumption by the cells, respectively. All data are shown as mean ±SEM (n = 5–8). *P<0.05, **P<0.01, ***P<0.001, t-test relative to LUC7L2WT. (C) Media acidification of LUC7L2KO K562 cells grown in glucose.