FIGURE 1.

Multivariable logistic regression model of failure to achieve corticosteroid-free remission. Model excludes patients who met criteria for corticosteroid-free remission (ie, HBI <5 and no use of systemic corticosteroids) at the time of ustekinumab dose intensification. Multivariable analysis assessed current opioid use, current corticosteroid use, perianal disease, HBI as a continuous variable, and prior surgery based on P-value <0.2 on univariate analysis. The final model includes only variables with P < 0.05 after forward selection.