TABLE 2.
Cox Proportional Hazards Model for Treatment Failure in Patients With CD Treated to Target of Clinical and Endoscopic Remission
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (y) | 0.995 | 0.980-1.012 | 0.580 | — | — | — |
| Female | 0.914 | 0.563-1.483 | 0.716 | — | — | — |
| Current smoker | 0.882 | 0.354-2.195 | 0.787 | — | — | — |
| Early CD* | 0.798 | 0.473-1.347 | 0.398 | — | — | — |
| Age at diagnosis (y) | ||||||
| A1 (≤16) | 1 | — | — | — | — | — |
| A2 (17-40) | 1.350 | 0.698-2.612 | 0.373 | — | — | — |
| A3 (>40) | 1.295 | 0.561-2.992 | 0.545 | — | — | — |
| Location of disease | ||||||
| L1 (ileum) | 1 | — | — | 1 | — | — |
| L2 (colon) | 0.545 | 0.274-1.087 | 0.085 | 0.700 | 0.317-1.546 | 0.378 |
| L3 (ileocolon) | 0.802 | 0.439-1.467 | 0.474 | 0.901 | 0.474-1.713 | 0.750 |
| Behavior of disease | ||||||
| B1 (nonstricturing and nonpenetrating) | 1 | — | — | 1 | — | — |
| B2 or B3 | 1.640 | 1.001-2.687 | 0.049 | 1.344 | 0.706-2.558 | 0.369 |
| History of perianal disease | 1.150 | 0.670-1.976 | 0.612 | — | — | — |
| History of abdominal surgery | 1.702 | 1.021-2.836 | 0.041 | 1.116 | 0.585-2.130 | 0.739 |
| Prior exposure to anti-TNF agent (before current therapy) | 1.769 | 1.087-2.878 | 0.022 | 1.703 | 1.033-2.806 | 0.037 |
| Time taken to achieve ER (mo) | 0.985 | 0.962-1.009 | 0.224 | — | — | — |
| Histologic remission | 0.584 | 0.362-0.943 | 0.028 | 0.574 | 0.352-0.936 | 0.026 |
*Definition of early CD: disease duration <2 years.
ER indicates endoscopic remission; HR, hazard ratio.