Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 11;27(8):1316–1327. doi: 10.1093/ibd/izab025

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIGURE 3. — EpOCs respond to stimulation with cytokines. A, mRNA expression of STAT1, IRF1, IDO, SOCS1, PDL1, PDL2, and CIITA in EpOCs from control patients (grey bars), patients with UC (red bars), and patients with PSC-UC (green bars), with no treatment (NT) and after 24 hours of stimulation with IFNγ (10 ng/mL). B, Immunofluorescent staining, with nuclei in blue, E-cadherin in green, and phospho-STAT3 (p-S3) in red in EpOCs untreated and stimulated with IL-22 for 15 minutes. Scale bar 100 μm. C, mRNA expression of SOCS3 and CXCL2 in EpOCs from control patients (grey bars), patients with UC (red bars), and patients with PSC-UC (green bars), with no treatment (NT) and after 24 hours of stimulation with IL-22 (10 ng/mL). Ordinary 1-way analysis of variance (Tukey test as recommended) was performed in the cytokine stimulation experiments. *P < 0.05, **P < 0.005. Error bars represent standard error of the mean.