Term	Term Definition
Treatment-resistant depression	Clinically impairing depression symptoms despite an adequate trial of an evidence-based psychotherapy and an antidepressant with Grade A evidence for treating depression in pediatric population (fluoxetine, escitalopram, or sertraline)
Treatment-refractory depression	Clinically impairing depression symptoms despite an adequate trial of an evidence-based psychotherapy and at least 2 antidepressants with Grade A evidence for treating depression including at least 1 with Grade A evidence in pediatric populations (fluoxetine, escitalopram, or sertraline)
Remission	Minimal symptoms of depression after treatment
Response	Substantial improvement in depression symptoms with treatment. Greater than a 50% improvement in depression symptoms
Partial response	Modest improvement in depression symptoms with treatment. Defined as a 25%–49% improvement in depression symptoms
Nonresponse	Minimal-to-no improvement in depression symptoms with treatment. Defined as a less than 25% improvement in depression symptoms