Table 8.
Tier | Performance targets |
---|---|
0 – Just Don’t Use It | R2 < 0.25 or RMSD > 100% |
1 – Qualitative | R2 0.25 to 0.50, RMSD < 100% |
2 – Semi-Quantitative | R2 0.50 to 0.75, RMSD < 50%, bias < 50% |
3 – Reasonably Quantitative | R2 0.75 to 0.90, RMSD < 20%, bias < 30% |
4 – Almost Regulatory | R2 > 0.90, RMSD < 10%, bias < 15% |