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. 2019 Jul 17;17(4):1038–1043. doi: 10.5114/aoms.2019.86622

Figure 3.

Figure 3

CYLD gene is a target of miR-130b in BUC cells. A – The binding site of miR-130b in the 3′UTR of CYLD. B – The expression of CYLD in doxorubicin-insensitive BUC patients was down-regulated compared with doxorubicin-sensitive BUC patients. *p < 0.05 vs sensitive group. C – The CYLD expression in J82/Dox and T24/Dox cells decreased compared with J82 and T24 cells. *p < 0.05 vs. J82 cells, #p < 0.05 vs. T24 cells. D – MiR-130b inhibited the relative luciferase activity by combining with wild-type binding site of CYLD. *p < 0.05 vs. miR-NC(+) + p-CYLDwt. E – MiR-130b reduced the expression of CYLD protein in J82/Dox and T24/Dox cells. *p < 0.05 vs. blank control or miR-NC(+)