Table 3.
The impact of central (WHtR) versus general obesity (BMI) on the risk of heart failure hospitalization or death in different stages of diabetic nephropathy
| Normoalbuminuria | Microalbuminuria | Macroalbuminuria | |
|---|---|---|---|
| HR (95% CI) | |||
| n (%) | 3324 (71.2) | 644 (13.8) | 700 (15.0) |
| WHtR (per 0.1) | 1.21 (0.86–1.70) | 2.33 (1.48–3.67) | 1.64 (1.26–2.13) |
| WHtR (per 1 SD) | 1.08 (0.87–1.35) | 1.72 (1.29–2.29) | 1.37 (1.16–1.62) |
| BMI (per 1 kg/m2) | 1.01 (0.95–1.07) | 1.07 (0.99–1.15) | 1.07 (1.03–1.12) |
| BMI (per 1 SD) | 0.99 (0.78–1.25) | 1.29 (0.97–1.71) | 1.28 (1.08–1.52) |
Multivariable Cox-regression model was adjusted for sex, age at onset of diabetes, duration of diabetes, glycated hemoglobin A1c, systolic blood pressure, HDL-cholesterol, triglycerides, history of smoking, lipid-lowering, antihypertensive and antidepressant medications, and estimated glomerular filtration rate
HR hazard ratio; CI confidence interval; SD standard deviation; WHtR waist-height ratio; BMI body mass index