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. 2021 Jul 27;14:121. doi: 10.1186/s13041-021-00833-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Effect of LIMK1-EGFP expression in 3-month old WT mice. A Normal social interaction during stage 2 of the three-chamber social test in WT mice expressing EGFP or LIMK1-EGFP (WT + EGFP n = 9, p < 0.001; WT + LIMK1-EGFP n = 7, p < 0.001; two-tailed paired t-test). B Preference for S2 over S1 during stage 3 of the three-chamber social test in WT mice expressing EGFP or LIMK1-EGFP (WT + EGFP n = 9, p < 0.001; WT + LIMK1-EGFP n = 7, p < 0.001; two-tailed paired t test). C Discrimination scores during stage 3 of three-chamber social test showing no difference in social memory between WT mice expressing EGFP and LIMK1-EGFP (p = 0.783, two-tailed t-test). D Both EGFP and LIMK1-EGFP expressing WT mice showed memory acquisition during trials 1–5 of the five-trial social memory assay (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7; genotype: F_(1,6) = 7.086, p = 0.037; trial: F_(4,24) = 9.180, p < 0.001; repeated two-way ANOVA for trial 1–5). On trial 6, WT + LIMK1-EGFP mice showed significantly decreased interaction time compared during the presentation of a novel mouse compared to WT + EGFP mice (p = 0.041, two-tailed t-test). E Open field test showing travel distance in WT mice expressing EGFP or LIMK1-EGFP (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.040, two-tailed t-test). F Average travel speed in pen field test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.040, two-tailed t-test). G Time spent in center arena in open field test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.360, two-tailed t-test). H Time spent in peripheral arena in open field test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.259, two-tailed t-test). I Travel distance in elevated plus maze test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.594, two-tailed t-test). J Time spent in closed arms in elevated plus maze test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.187, two-tailed t-test). K Time spent in open arms in elevated plus maze test (WT + EGFP n = 10, WT + LIMK1-EGFP n = 7, p = 0.188, two-tailed t-test). Data are presented as mean ± s.e.m. n = number of mice. *p < 0.05, ***p < 0.001, ns = not significant