Fig. 9.

Construction of gene-based prognostic model and evaluation of the nomogram. A: Nomogram integrated six-gene based risk score, AJCC pathological stage, gender, and age. B-D: The calibration plot of the nomogram for agreement test between 1-, 3- and 5-year OS prediction and actual outcome in TCGA dataset. E-G: Decision curve analysis for 1-, 3- and 5-year OS prediction based on nomogram in TCGA dataset. Blue line: assume no patient is at high-risk. Green line: assume all patients are at high-risk. These two lines serve as a reference. Red line: nomogram can provide more net benefits for BLCA patients’ survival prediction. H: The time-dependent ROC curves of the nomogram in TCGA dataset. TCGA: the Cancer Genome Atlas. ROC: Receiver operating characteristic