Table 2.

Univariate and multivariate Cox regression analysis for predicting OS of PUC

	Univariate analysis			Multivariate analysis
	HR	95%CI	p value	HR	95%CI	p value
Age
<70	Ref			Ref
≥ 70	1.906	1.667–2.179	<0.001*	1.948	1.693–2.242	<0.001*
Sex
Male	Ref
Female	0.919	0.803–1.051	0.281
Race
White	Ref
Black	1.102	0.937–1.297	0.241
Other	1.050	0.786–1.404	0.741
Grade
I	Ref			Ref
II	1.192	0.847–1.678	0.313	1.207	0.893–1.632	0.220
III	1.407	1.014–1.953	0.041*	1.156	0.862–1.550	0.334
IV	1.342	0.961–1.874	0.085	1.214	0.895–1.646	0.213
Histology
SCC	Ref
TCC	1.122	0.957–1.314	0.155	0.899	0.749–1.079	0.251
AC	0.906	0.737–1.114	0.301	0.765	0.619–0.946	0.014*
Other	1.289	1.037–1.601	0.022*	0.898	0.717–1.126	0.352
T stage
T0/T1	Ref			Ref
T2	1.105	0.913–1.337	0.307	1.125	0.773–1.636	0.539
T3	1.577	1.313–1.894	<0.001*	1.444	1.059–1.969	0.020*
T4	2.144	1.738–2.646	<0.001*	1.788	1.273–2.512	<0.001*
N stage
N0	Ref			Ref
N1	1.530	1.239–1.891	<0.001*	1.057	0.837–1.333	0.643
N2	1.810	1.464–2.238	<0.001*	1.413	1.073–1.862	0.014*
M stage of BC
M0	Ref			Ref
M1	4.646	3.845–5.615	<0.001*	3.080	2.377–3.990	<0.001*
AJCC stage groups
I	Ref			Ref
II	1.075	0.859–1.345	0.528	1.015	0.661–1.558	0.947
III	1.271	1.030–1.570	0.026*	1.037	0.722–1.490	0.843
IV	2.685	2.247–3.209	<0.001*	0.973	0.658–1.438	0.891
Tumor size, mm
<30	Ref			Ref
≥ 30	1.662	1.307–2.115	<0.001*	1.369	1.176–1.594	<0.001*
Surgery
No surgery	Ref			Ref
Local therapy	0.599	0.511–0.701	<0.001*	0.832	0.700–0.989	0.037*
Radical therapy	0.458	0.389–0.539	<0.001*	0.626	0.524–0.746	<0.001*
Radiation
No/Unknown	Ref
Yes	1.003	0.866–1.162	0.966
Chemotherapy
No/Unknown	Ref
Yes	0.984	0.855–1.134	0.826

OS Overall survival, PUC Primary urethral carcinoma, HR Hazard ratio, CI Confidence interval, Ref Reference, AJCC American Joint Committee on Cancer

Grade: Grade I (Well differentiated); Grade II (Moderately differentiated); Grade III (Poorly differentiated); Grade IV (Undifferentiated)