Table 2.
Comparisons of demographic, laboratory, and clinical parameters between patients with IDA+RLS vs patients with IDA−RLS or iRLS.
| IDA+RLS (n = 50) | IDA−RLS (n = 74) | P* | iRLS (n = 50) | P† | |
|---|---|---|---|---|---|
| Age, y | 54.02 ± 12.50 | 47.22 ± 12.35 | .003 | 51.98 ± 9.34 | .358 |
| Sex, female, n (%) | 45 (90.0) | 64 (86.5) | .780‡ | 44 (88.0) | > .99‡ |
| Previous illness, yes, n (%) | 27 (57.4) | 31 (43.1) | .125 | 20 (40.0) | .086 |
| Current medication, yes, n (%) | 26 (54.2) | 28 (39.4) | .113 | 19 (41.3) | .212 |
| Hemoglobin, g/dL | 10.27 ± 1.36 | 8.70 ± 1.62 | < .001 | 13.68 ± 1.01 | < .001 |
| Iron, μg/dL | 33.86 ± 24.22 | 26.37 ± 36.96 | .231 | 100.59 ± 31.15 | < .001 |
| TIBC, μg/dL | 411.19 ± 66.32 | 426.54 ± 54.99 | .202 | 328.90 ± 47.07 | < .001 |
| TSAT, % | 8.61 ± 6.44 | 6.31 ± 8.89 | .140 | 30.86 ± 9.87 | < .001 |
| Ferritin, ng/mL | 9.53 ± 8.98 | 10.82 ± 30.21 | .771 | 68.50 ± 55.91 | < .001 |
| IDA duration, y | 3.28 ± 2.14 | 3.04 ± 1.92 | .516 | ||
| IDA treatment, yes, n (%) | 3 (6.0) | 14 (18.9) | .060‡ | ||
| IRLSS, n (%) | 27.92 ± 6.80 | 27.22 ± 6.79 | .613 | ||
| Mild (1–10) | 0 | 2 (4.0) | .495‡ | ||
| Moderate (11–20) | 7 (14.0) | 5 (10.0) | .549‡ | ||
| Severe (21–30) | 20 (40.0) | 29 (58.0) | .157‡ | ||
| Very severe (31–40) | 21 (42.0) | 14 (28.0) | .140‡ | ||
| RLS QoL | 57.94 ± 23.51 | 58.79 ± 22.47 | .858 | ||
| RLS duration, y | 7.47 ± 9.71 | 14.70 ± 12.56 | .003 | ||
| ISI | 17.24 ± 6.01 | 6.11 ± 5.31 | < .001 | 15.86 ± 6.14 | .260 |
| PSQI total | 13.02 ± 3.78 | 6.00 ± 3.24 | < .001 | 11.92 ± 4.82 | .210 |
| BDI | 17.55 ± 11.87 | 9.64 ± 7.62 | < .001 | 12.92 ± 7.62 | .024 |
| BAI | 15.68 ± 10.27 | 5.53 ± 5.64 | < .001 | 10.6 ± 8.85 | .027 |
| SF-36 total | 51.96 ± 23.11 | 72.37 ± 17.10 | < .001 | 57.31 ± 20.48 | .230 |
*P value for IDA+RLS vs IDA−RLS. †P value for IDA+RLS vs iRLS. ‡Fisher exact test. Analysis of covariance: age correction. BAI = Beck Anxiety Inventory, BDI = Beck Depression Inventory, IDA = iron deficiency anemia, IDA+RLS = iron deficiency anemia with restless legs syndrome, IDA−RLS = iron deficiency anemia without restless legs syndrome, iRLS = idiopathic restless legs syndrome, IRLSS = International Restless Legs Syndrome Study Group Severity Scale, ISI = Insomnia Severity Index, PSQI = Pittsburgh Sleep Quality Index, QoL = quality of life, RLS = restless legs syndrome, SF-36 = Short Form-36 health survey, TIBC = total iron-binding capacity, TSAT = transferrin saturation.