Table 2.
Characteristics of patients in included studies.
| Study | Mean Age (years) | Male (%) | BMI | AHI (events/h) | OAHI (events/h) | CAHI (events/h) | Side Effect of Acetazolamide |
|---|---|---|---|---|---|---|---|
| Central | |||||||
| DeBacker et al, 199520 | 47.9 ± 2.8 | 92.9 | 31.5 ± 1.7 | 37.2 ± 6.2 | 3.5 ± 1. 5 (OAI) | 25.5 ± 6.8 (CAI) | Some paresthesia |
| Fontana et al, 201122 | 62 ± 9 | 91.7 | 29 ± 4 | 36 ± 16 | NR | NR | NR |
| Ginter and Sankari, 202036 | Able-bodied: 59.5 ± 11.8; Spinal cord injury: 50.3 ± 12.8 | 81.25 | Able-bodied: 29.2 ± 1.9; Spinal cord injury: 25.8 ± 2.8 | Able-bodied: 21.3 ± 13.8; Spinal cord injury: 27.2 ± 32.0 | Able-bodied: 1.7 ± 2.0 (OAI); Spinal cord injury: 2.8 ± 3.7 (OAI) | Able-bodied: 2.8 ± 4.5 (CAI); Spinal cord injury: 7.3 ± 14.6 (CAI) | NR |
| Javaheri 200624 | 66 ± 6 | 100 | 26.4 ± 4.2 | 55 ± 24 | 1 ± 2 | 44 ± 23 | 8% nocturia |
| Naghan et al, 201925 | 50.2 ± 13.6 | 90 | 29.6 ± 6 | 78.2 ± 39.9 | 1.7 (0.7–19.8)(OAI) | 17.8 (13.3–24.8)(CAI) | NR |
| Ulrich et al, 201529 | 66 (56–71) | 34.8 | 26.6 (25.2–29.3) | 18 (6–40) | NR | NR | NR |
| Verbraecken et al, 199830 | 46 ± 5 | 87.5 | 30 ± 1 | 39 ± 10 | 3 ± 2 | 25 ± 10 | Some paresthesia |
| White et al, 198231 | 57.67 ± 13.63 | 100 | NR | 54 ± 12 (AI) | NR | NR | 33.3% paresthesia and released after dose reduced |
| Obstructive | |||||||
| Eskandari et al, 201821 | 64 ± 7 | 100 | 29 ± 4 | 37 ± 23 | NR | NR | 46% paresthesia, 31% dyspepsia |
| Whyte et al, 198832 | 51.50 ± 11.21 | 80 | NR | 50 ± 26 | NR | NR | 80% paresthesia |
| Unknown and Mixed Type | |||||||
| Apostolo et al, 201419 | 69.1 ± 1.9 | 100 | 24.5 ± 3.33 | 30.8 ± 13.8 | NR | NR | NR |
| Inoue et al, 199923 | 55.2 | 88.0 | 25.6 | 27.1 ± 17.4 | NR | NR | NR |
| Sakamoto et al, 199526 | 54.6 | 100 | NR | 34 ± 23.9 (AI) | NR | NR | 50% numbness,10% pollakiuria and 5% thirst |
| Sharp et al, 198527 | 53.6 ± 10.99 | NR | 33.55 ± 8.81 | OSA: 89 ± 4.9 CSA: 83 ± 35.36 MSA: 64.75 ± 17.39 | NR | NR | NR |
| Tojima et al, 198828 | 58 ± 4 | 55.6 | 29.86 ± 6.15 | 25 ± 6.7 | NR | NR | 22.2% dysesthesia and 11.1% pollakiuria |
AHI = apnea-hypopnea index, AI = apnea index, BMI = body mass index, CSA = central sleep apnea, MSA = mixed sleep apnea, NR = not reported, OAI = obstructive apnea index, OSA = obstructive sleep apnea.