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The effect of protopine on the tumour growth in xenograft mice. A tumour volume change in HepG2 and Huh-7 group after treated with protopine. B tumor weight was measured after mice were sacrificed. C body weights of mice were measured during the study. D tumours were resected and subjected to western blotting with indicated antibodies. Data were presented as mean ± SD; *P < 0.05; **P < 0.01
