Table 2.
MoCA Score Classified by Age, Education, BMI, and Various Biochemical Parameters
| Biochemical Variables | N | Total Score | Visuospatial/Executive Score=5 | Naming Score=3 |
Attention Score=6 |
Language Score=3 |
Abstraction Score=2 | Memory Score=5 |
Orientation Score=6 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Age (y) | 45–55 | 147 | 26.3±2.7 | 4.6±0.67 | 2.99±0.08 | 5.67±0.63 | 1.69±0.87 | 1.66±0.65 | 3.63±1.58 | 5.87±0.12 |
| 56–65 | 289 | 24.6±3.1* | 4.4±0.91* | 2.94±0.24* | 5.49±0.91* | 1.63±1.02 | 1.57±0.70 | 3.03±1.7* | 5.96±0.39 | |
| Education (y) | ˂12 | 106 | 24.1±3.8 | 3.95±1.08 | 2.89±0.34 | 5.15±1.19 | 1.25±0.94 | 1.31±0.82 | 3.11±1.79 | 5.96±0.24 |
| ≥12 | 330 | 26.1±2.8* | 4.67±0.66* | 2.98±0.13* | 5.68±0.62* | 1.78±1* | 1.69±0.61* | 3.89±1.65* | 5.97±0.34 | |
| BMI (kg/m2) | ˂25 | 237 | 25.5±3.3 | 4.53±0.82 | 2.97±0.19 | 5.81±0.58 | 1.67±1.04 | 1.60±0.67 | 3.15±1.75 | 5.96±0.42 |
| ≥25 | 199 | 24.8±2.1* | 4.46±0.87 | 2.95±0.22 | 5.01±0.26* | 1.62±0.99 | 1.59±0.70 | 3.33±1.61 | 5.98±0.12 | |
| Glucose (mg/dL) | ˂110 | 291 | 25.5±3.2 | 4.51±0.81 | 2.95±0.22 | 5.54±0.85 | 1.69±1.0 | 1.62±0.68 | 3.13±1.71 | 5.96±0.39 |
| ≥110 | 150 | 23.9±4.2* | 4.46±0.89 | 2.97±0.16 | 4.96±0.42* | 1.59±1.06 | 1.57±0.70 | 3.44±1.63 | 5.99±0.08 | |
| TC (mg/dL) | ˂200 | 163 | 25.5±3.1 | 4.5±0.83 | 2.98±0.13 | 5.56±0.72 | 1.64±1.04 | 1.55±0.70 | 3.09±1.75 | 5.96±0.47 |
| ≥200 | 273 | 25.7±3.2 | 4.49±0.85 | 2.95±0.24 | 5.54±0.89 | 1.66±1.01 | 1.63±0.67 | 3.32±1.65 | 5.97±0.18 | |
| HDL (mg/dL) | >40 | 50 | 25.5±3.1 | 4.46±0.86 | 2.96±0.28 | 5.56±0.64 | 1.47±1.07 | 1.64±0.66 | 3.32±1.16 | 5.98±0.14 |
| ≤40 | 386 | 25.6±3.2 | 4.5±0.84 | 2.96±0.19 | 5.55±0.85 | 1.68±1.01 | 1.6±0.69 | 3.22±1.69 | 5.97±0.34 | |
| LDL (mg/dL) | ˂130 | 60 | 25.7±2.9 | 4.58±0.81 | 2.94±0.43 | 5.58±0.74 | 1.68±1.0 | 1.58±0.72 | 3.07±1.20 | 5.88±0.00 |
| ≥130 | 375 | 23.9±3.2* | 4.12±0.21* | 2.69±0.56 | 5.55±0.84 | 1.65±1.02 | 1.60±0.68 | 3.26±1.17 | 5.45±0.34 | |
| Triglyceride (mg/dL) | ˂150 | 290 | 25.6±3.1 | 4.51±0.8 | 2.97±0.17 | 5.57±0.59 | 1.66±0.99 | 1.61±0.67 | 3.25±1.02 | 5.59±0.37 |
| ≥150 | 146 | 24.5±3.3* | 4.47±0.92 | 2.94±0.26 | 5.01±0.41* | 1.64±1.07 | 1.58±0.72 | 3.21±1.62 | 5.98±0.18 | |
| Blood mercury (µg/L)a | Tertile 1 | 26.34±4.12 | 4.46±1.26 | 2.97±0.23 | 5.68±0.69 | 1.62±0.94 | 1.57±0.36 | 3.97±1.32 | 5.92±0.24 | |
| Tertile 2 | 24.92±2.48 | 4.32±0.97 | 2.94±0.34 | 5.33±0.87 | 1.78±1.08 | 1.68±0.59 | 3.48±0.96 | 5.99±0.31 | ||
| Tertile 3 | 23.98±4.6# | 4.11±0.58# | 2.91±0.19 | 4.48±0.57# | 1.57±1.12 | 1.56±0.47 | 3.11±1.04# | 5.94±0.44 | ||
| Homocysteine (µmol/L) | <15 | 290 | 25.7±2.6 | 4.46±0.86 | 2.91±0.23 | 5.61±0.73 | 1.67±1.03 | 1.59±0.69 | 3.69±1.04 | 5.98±0.36 |
| ≥15 | 146 | 24.71±4.2* | 4.56±0.81 | 2.98±0.14 | 5.43±0.98 | 1.63±1.0 | 1.62±0.67 | 3.07±0.87* | 5.72±0.23 |
Notes: aGeometric mean of blood mercury level, *Significant difference from compared groups, # Significant difference from blood mercury tertile 1 with P<0.05.
Abbreviations: MoCA, Montreal Cognitive Assessment; BMI, body mass index; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.