Fig. 2.

Overview of potential protective mechanisms for coping with the lysosome depletion. Different repair mechanisms have been discovered to restore the function of lysosome depending on the extent of lysosomal damage, mainly through 3 potential mechanisms: the rescue of slightly damaged lysosomes mediated by ESCRT machinery, the removal of severely damaged lysosomes via lysophagy, and lysosome biogenesis regulated by TFEB that coordinately replenish intact lysosomes for restoring lysosome function and improving autophagic clearance, which may provide a potential therapy strategies for the management of kidney diseases. ESCRT, the endosomal sorting complex required for transport; mTOR, mammalian target of rapamycin; AMPK, AMP-activated protein kinase; TFEB, transcription factor EB.