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. 2021 Mar 10;7(4):293–305. doi: 10.1159/000513884

Fig. 3.

Fig. 3

Podocyte conditional Sirt1 knockout aggravated Aldo-induced albuminuria and renal pathology. Male WT and cKO mice were infused with Aldo (300 μg/kg/day) for 2 weeks. a qRT-PCR analysis of Sirt1. Measurement of urine albumin levels (albumin-to-Cr ratio) (b) and PAS staining (c). Results are presented as means ± SEM (n = 6). *p < 0.05 versus the WT + sham group. #p < 0.05 versus WT + Aldo. Sirt1, silent mating type information regulation 2 homolog 1; WT, wild type; cKO, conditional knockout; PAS, periodic acid-Schiff.