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Deletion of Sirt1 in podocyte-aggravated MtD. Mitochondrial morphology in glomerular podocytes (×50,000) (a) and mtDNA copy number (b). Results are presented as means ± SEM (n = 6). *p < 0.05 versus the WT + sham group. #p < 0.05 versus WT + Aldo. Sirt1, silent mating type information regulation 2 homolog 1; WT, wild type; mtDNA, mitochondrial DNA; MtD, mitochondrial dysfunction.
