Table 1. Lyme disease in the United States and Europe.

Variable	United States	Europe
Tick vector	Ixodes scapularis, I. pacificus	I. ricinus, I. persulcatus
Lyme borrelia	Mostly Borrelia burgdorferi sensu stricto; B. mayonii may occur in the upper midwestern United States	Mostly B. afzelii and B. garinii, but several other species cause human disease, including B. burgdorferi s.s., B. bavariensis, B. spielmanii, and B. lusitaniae
Speed of tick transmission of Lyme borrelia	Rarely before 36 h	I. ricinus ticks may transmit B. afzelii within 24 h
Predominant patient sex	Male patients account for 56% of reported cases during 2001–2018; no manifestation is predominant among female patients	Most cases of erythema migrans and acrodermatitis chronica atrophicans occur in women; neuroborreliosis and arthritis are predominant in men
Coinfections	Risk depends on the geographic area; the most common co-infections are anaplasmosis and babesiosis.	Risk depends on the geographic area; the most common co-infection is tick-borne encephalitis