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. 2021 May 1;203(9):1099–1111. doi: 10.1164/rccm.202005-1596OC

Figure 2.

Figure 2.

Differential gene expression demonstrates inflammation up to 14 days after aspiration with a mixture of human oral commensals (MOC). (A) PC analysis of gene expression based on the Bray-Curtis dissimilarity index (permutational multivariate ANOVA P = 0.003). (B and C) Ingenuity pathway analysis network analysis for transcriptomic changes after MOC aspiration on Day 1 (D1) and D14, respectively. (D) Ingenuity pathway analysis on differentially expressed genes between MOC versus PBS for D1 and D14 (false discovery rate < 0.1). NK = natural killer cell; P = phosphorylation/dephosphorylation; PBS = phosphate-buffered saline; PC = principal coordinate; ROS = reactive oxygen species; Th = T-helper cell; Ub = Ubiquitination.