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. 2021 May 1;203(9):1099–1111. doi: 10.1164/rccm.202005-1596OC

Figure 6.

Figure 6.

Modulation of host susceptibility to Streptococcus pneumoniae after aspiration with a mixture of human oral commensals (MOC). (A) Schematic of experiment with MOC exposure and pathogen challenge with low dose of S. pneumoniae. (B) Recovery of S. pneumoniae at 24 hours after pathogen challenge. Box and whisker plots demonstrate median (interquartile range) with minimum to maximum values. *P < 0.05. (C) Schematic of experiment with MOC exposure and pathogen challenge with a medium (6.5 × 108 cfu/ml) and high dose (2.67 × 109 cfu/ml) of S. pneumoniae (phosphate-buffered saline [PBS] n = 5, MOC coexposure n = 5, and MOC preexposure n = 5). (D) Survival curves of mice after pathogen challenge (P value based on Mantel-Cox; PBS n = 5, MOC preexposure n = 5). Coexp = coexposure.