Table 9.

2007 Infectious Diseases Society of America/American Thoracic Society Criteria for Severe CAP

Validated definition includes either one major criterion or three or more minor criteria

Minor criteria

• Respiratory rate > 30 breaths/min; PaO2/FiO2 ratio < 250

• Multilobar infiltrates

• Confusion/disorientation

• Uremia (blood urea nitrogen level > 20 mg/dl)

• Leukopenia* (white blood cell count < 4,000 cells/ml)

• Thrombocytopenia (platelet count < 100,000/ml)

• Hypothermia (core temperature < 36.8°C)

• Hypotension requiring aggressive fluid resuscitation

Major criteria

• Septic shock with need for vasopressors

• Respiratory failure requiring mechanical ventilation

Definition of abbreviation: CAP = community-acquired pneumonia.

The same criteria were used by the 2019 CAP guideline (2).

^*Due to infection alone (i.e., not chemotherapy induced).