Figure 2.

⁶⁸Ga-CBP8 positron emission tomography (PET) in pulmonary fibrosis. (A) Computed tomography (CT) performed 1 year prior to PET–magnetic resonance imaging (MRI). (B) CT performed 6 weeks prior to PET–MRI. Note the progression of interstitial fibrosis on the CT over time (arrows). (C) ⁶⁸Ga-CBP8 PET demonstrates areas of high probe uptake in peripheral portions of the right upper lobe (arrows), corresponding to reticulation and ground-glass opacity (interstitial fibrosis) seen on ultrashort echo time MRI (D). The high probe uptake (C) is seen predominately in regions of progressive fibrosis in the peripheral right upper lobe. The uptake in the heart and vasculature as well as in the liver is to be expected based on the probe’s half-life and biodistribution. Scale bar denotes standardized uptake values for C.