. Author manuscript; available in PMC: 2021 Jul 27.

Published in final edited form as: J R Stat Soc Ser A Stat Soc. 2020 May 8;183(4):1705–1726. doi: 10.1111/rssa.12570

Table 2.

Results of causal mediation analysis

	Mediators: brain hypoperfusion and white matter disease
	OR	90% CI	p-value
MCI or dementia^†
Total effect	1.51	(1.22, 1.86)	< 0.01
Direct effect	1.31	(1.01, 1.72)	0.09
Indirect effect	1.15	(0.98, 1.35)	0.16
MCI^‡
Total effect	1.54	(1.21, 1.95)	< 0.01
Direct effect	1.31	(0.98, 1.75)	0.13
Indirect effect	1.18	(0.99, 1.40)	0.12
Dementia^§
Total effect	1.56	(1.16, 2.11)	0.01
Direct effect	1.30	(0.87, 1.94)	0.28
Indirect effect	1.20	(0.91, 1.58)	0.28

^†

A total of N = 2872 CHS participants were included in this analysis, of which 842 (29.3%) were classified as having MCI or dementia.

^‡

A total of N = 2511 CHS participants were included in this analysis, of which 481 (19.2%) were classified as having MCI.

^§

A total of N = 2391 CHS participants were included in this analysis, of which 361 (15.1%) were classified as having dementia.