Table 5.
Comparisons among Palliative/HF Clinical Trials: ENABLE CHF-PC, CASA, and PAL-HF.
| ENABLE CHF-PC (N = 415) | CASA (n = 314) | PAL-HF (n = 150) | |
|---|---|---|---|
| Age, mean (SD) | 63.8 (8.6) | 65.5 (11.4) | 70.85 (12.9)* |
| African American, n (%) | 226 (54) | 64 (20) | 62 (41) |
| Male n (%) | 221 (53) | 247 (79) | 79 (53) |
| NYHA Class III, n (%) | 401 (97) | 150 (47) | 112 (75) |
| NYHA Class IV, n (%) | 11 (3) | 44 (14) | 20 (13) |
| Baseline KCCQ Clinical Summary Score, mean (SD) | 52.5 (21) | 46.9 (19.2)* | 33.7 (18.2)* |
| 12–16 Weeks | 58.2 (22.7) | 51.75 | 56.15 (23.8) |
| 24 Weeks | 58.6 (24.4) | 52.45 | 57.6 (22.8) |
| FACIT-PAL 14, mean (SD) | 36.4 (9.5) | NA | NA |
| FACIT-PAL, mean (SD) | NA | NA | 119.3 (26.1)* |
| HADS**, mean (SD) | |||
| Anxiety | 6.7 (3.6) | NA | 6.45 (4.7) |
| Depression | 5.7 (4.3) | NA | 6.65 (4.1) |
| PHQ-9, median (IQR) | NA | 9 (5–14) | NA |
ENABLE CHF-PC = Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcarefor Patients and Caregivers; CASA = Collaborative Care to Alleviate Symptoms and Adjust to Illness; PAL-HF = Palliative Care in Heart Failure; NYHA = New York Heart Association; KCCQ = Kansas City Cardiomyopathy Questionnaire; FACIT Pal = Functional Assessment of Chronic Illness Therapy-Palliative; HADS = Hospital Anxiety and Depression Scale; PHQ-9 = Patient Health Questionnaire 9.
*
pooled SDs from intervention and usual care groups
**
PAL-HF HADS baseline measurement at 2 weeks.