Table 1.
Observed methionine dependence of various cancer cell lines.
| Citation | Type of cancer | Cell lines | Met dependence (Ccomplete, ++, partial. +independent, − |
|---|---|---|---|
| Najim et al. (2009)[8] | Central nervous system | Daoy (medulloblastoma) | ++ |
| D-54 (glioma) | ++ | ||
| Kokkinakis et al. (2001)[9] | Brain | D-54 | ++ |
| SWB77 (glioblastoma) | ++ | ||
| Daoy | ++ | ||
| Willmann et al.(2015)[10] | Breast cancer | epithelial cell line MCF-10A | ++ |
| Kano et al. (1982)[11] | Leukemia | Raji (Burkitt) | ++ |
| BALL (B-cell) | ++ | ||
| TALL (T-cell) | ++ | ||
| MOLT-3 (T-cell) (−) | − | ||
| MOLT 4B (T-cell) | ++ | ||
| HL60 (promyelocytic ) | ++ | ||
| K562 (chronic myelogenous leukemia in blastic crisis) | ++ | ||
| Poirson-Bichat et al.(2000)[12] | Colon, lung, glioma | TC71-MA (colon) | ++ |
| SCLC6 (small cell lung) | ++ | ||
| SNB19 (glioma) | ++ | ||
| Lu et al.(2000)[13] | Prostate | LNCaP (lymph node metastasis) | − |
| PC-3 (distant metastasis) | ++ | ||
| DU 145(distant metastasis) | + | ||
| Guo et al.(1993)[14] | Prostate, lung, fibrosarcoma | PC3 | ++ |
| SKLU-I (lung carcinoma) | ++ | ||
| HT 1080 (fibrosarcoma) | ++ | ||
| Mecham et al.(1983)[15] | Bladder, breast, cervical, colon, kidney, lung, prostate, fibrosarcoma, osteogenic sarcoma, glioblastoma, neuroblastoma | EJ (bladder) | ++ |
| J82 (bladder) | ++ | ||
| SK-BR-2-II (breast) | ++ | ||
| MCF-7 (breast) | ++ | ||
| HeLa (cervical) | ++ | ||
| SK-CO-1 (colon) | ++ | ||
| A498 (kidney) | ++ | ||
| A2182 (lung) | ++ | ||
| PC-3 | ++ | ||
| 8387 (fibrosarcoma) | ++ | ||
| HT-1080 | ++ | ||
| HOS (osteogenic sarcoma) | ++ | ||
| Human neurological tumors | ++ | ||
| A172 (glioblastoma) | ++ | ||
| SK-N-SH (neuroblastoma) | ++ |