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. 2021 Jun 22;17(10):2606–2621. doi: 10.7150/ijbs.60292

Figure 1.

Figure 1

H&E staining and immunohistochemical staining of pyroptosis-related proteins in fine-needle aspiration biopsy (pre-NACT) and resected specimens (post-NACT) from 20 matched breast cancer biopsies. A) H&E staining in matched pre- and post-NACT tumor specimens. Blue arrows indicated the tumor cells with pyroptosis-like changes. Black arrows indicated inflammatory cells around the tumor bed. B) Immunohistochemical staining of GSDMD, NLRP3, caspase-1, IL-18, and IL-1β expression in matched pre- and post-NACT tumor specimens. Scale bar, 50 µm. ***P < 0.001.