Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 16;17(10):2523–2536. doi: 10.7150/ijbs.59430

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

The mechanism of MUC3A knockdown induced more DNA damages by X-rays. (A) Immunoblotting analysis of p-ATM, p-ATR, γ-H2AX, BRCA1, RAD51, XCRR6, and HIF1α protein levels after 4 Gy irradiation. (B) Immunoblotting analysis to investigate the plasm and nucleus protein levels of GADD45, TP53, and p65. (C) Representative images of GADD45 in H1975 and H1299 cells after 4 Gy irradiation. (D) As previously described, specific software was used to analyze the co-localization of γ-H2AX and DADD45. In MUC3A-knockdown cells, less GADD45 was recruited to γ-H2AX. *, p < 0.05.