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. 2021 Jun 11;17(10):2430–2448. doi: 10.7150/ijbs.61012

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Hyp mice displayed an identical osteomalacia phenotype as that for the Dmp1 KO long bone (Representative data from 3-6 animals for each assay). (a). X-ray images displayed very similar changes in osteomalacia long bones from Hyp and Dmp1-mice. (b). Acid-etched SEM images showed a great increase in osteoid within the Hyp long bone (arrow) plus a defect in Ocy morphologies (an increase in cell body and dendrite thickness and a rough surface). (c). Goldner staining showed a great increase in osteoid in the Hyp bone. (d). DMP1 immunostaining revealed no apparent change in DMP1 expression level except for a pattern change in the Hyp bone. (e-f). Quantitative data displayed a significant increase in b-catenin in Hyp mRNAs (e, n = 6; p < 0.01) and proteins (f, n = 6; p < 0.001) in Hyp long bones compared to the age matched wild type long bones.